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Dear Subscriber,

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VeinSense, quickly deals with swollen
legs and ankles, hemorrhoids, varicose
veins, chronic venous insufficiency
and even spider veins.

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VeinSense^TM
for Varicose Veins, Hemorrhoids and Edema

What to expect from VeinSense:

• Supports vein health and reduces varicose veins
• Helps decrease the edema and inflammation associated with varicose veins
• Eliminates heavy feeling legs and swelling of legs
• Reduces Chronic Venous Insufficiency (CVI)
• Reduces phlebitis
• Eliminates hemorrhoids
• Helps relieve symptoms of lymphedema
• Helps heal leg ulcers
• Aids PMS

The key ingredients in VeinSense include: Diosmin, Horse chestnut, Butcher’s broom and Hesperidin. Each of these ingredients has beneficial effects on vein health and treatment of varicose veins, leg swelling, hemorrhoids, PMS and more…

Diosmin
Diosmin is a naturally occurring flavonoid glycoside isolated from various plants and the flavonoid hesperidin. Diosmin is a vascularprotecting agent used to treat chronic venous insuficiency, hemorrhoids, lymphedema, and varicose veins. Diosmin is also a powerful antiinflammatory and free-radical scavenging agent. Diosmin should also be used for dermatitis and wound healing.

Diosmin is derived by extracting hesperidin from citrus rinds, followed by conversion of hesperidin to diosmin. Diosmin has been used for more than 30 years as a vein tonic and vascularprotecting agent. It is now being researched for cancer, premenstrual syndrome, colitis, and diabetes.

Diosmin improves vein tone, increases lymphatic drainage, protects capillaries, inhibits inflammation, and reduces capillary fragility and permeability.

Diosmin and Varicose Veins/Chronic Venous Insufficiency
Chronic venous insufficiency is characterized by pain, leg heaviness, a sensation of swelling and cramps, and is often seen in those with varicose veins. A multicentre international trial involving 5,052 people with chronic venous insufficiency evaluated Diosmin. Patients were treated with 450 mg diosmin and 50 mg hesperidin daily for six months. Continuous clinical improvement was found throughout the study, as well as improvements in quality of life scores for participants.

Diosmin has also been effective in treating severe stages of chronic venous insufficiency, including venous ulceration and delayed healing. In a randomized multicentre trial, 900 mg diosmin and 100 mg hesperidin was given to patients in the treatment group. Complete healing of ulcers less than 10 cm in diameter was found.

Diosmin and Hemorrhoids
Several large clinical trials have demonstrated diosmin to be effective in the treatment of acute and chronic symptoms of hemorrhoids. A doubleblind, placebo-controlled study of 120 patients showed improvement of pain, pruritis, discharge, edema, erythema, and bleeding on examination. The treatment group was given diosmin and hesperidin for two months. Elimination of acute and chronic hemorrhoids was successful.

Diosmin and Lymphedema
Diosmin acts on the lymphatic system by increasing lymph flow and lymph oncotic pressure. Diosmin was used to treat upper limb lymphedema secondary to conventional therapy for breast cancer. Results showed improvement of symptoms and limb volume; the mean decrease in volume of the swollen limb reached 6.8 percent.

There are no documented cases of adverse interactions between diosmin and prescription medications.

Horse Chestnut
Horse Chestnut extract is used for the treatment of the symptoms of venous insuffciency (including pain and heaviness in the legs), night time cramps in the calves, and itchy, swollen legs; along with phlebitis and varicose veins. It is also effective for hemorrhoids, skin inflammation and premenstrual syndrome.

Aescin, the active ingredient in horse chestnut, tones the walls of the veins, improving the flow of blood back to the heart. It also relieves swelling by stopping excessive leakage through the walls of the capillaries (the tiny vessels that deliver blood to the tissues).

Horse Chestnut’s ability to relieve swelling in the legs has been confirmed in several rigorous clinical trials where it proved to be as effective as the uncomfortable compression stockings that are often prescribed.

For example, a 1996 study involving 240 patients, reported that horse chestnut seed extract (aescin, 50 mg twice a day) provided the same relief from lower leg swelling (edema) as compression (support) stockings.

An analysis of 13 clinical trials published in Archives of Dermatology in 1998 found Horse chestnut extract was significantly better than a placebo in relieving vein-related leg problems such as varicose veins.

Painful and inflamed hemorrhoids subside with the addition of horse chestnut extract for the same reasons that the remedy is so effective for varicose veins. By strengthening and toning the veins, as well as actually lessening swelling and fluid retention in the body, the hemorrhoid—a swollen vein itself—can recede.

Butcher’s broom extract
Butcher’s broom (Ruscus aculeatus) has been shown in several clinical trials to reduce varicose veins and hemorrhoids, and to treat the itching and burning of hemorrhoids. It is also used to help treat lower leg discomfort, including cramps, pain, itching and swelling, caused by pooling of blood in the veins. Research has also evaluated the combination of butcher’s broom along with hesperidin and horse chestnut extract.

A 1994 review of the pharmacological studies indicated that butcher’s broom extract exerts activity on the three levels of circulation involved in chronic venous insufficiency. It acts on lymphatic drainage, the constriction of blood vessels and microcirculation. When used in combination with the other ingredients in VeinSense, it also improves the strength of veins and reduces permeability. Butcher’s broom has been found to reduce blood pooling in the lower leg and also the size of the ankle and lower leg. Butcher’s broom also reduces enlarged veins.

During a 2-month treatment period with butcher’s broom extract in a randomized, double-blind, placebo-controlled trial involving 60 patients with CVI, a significant reduction in heavy legs, tired legs, evening edema, pain, pruritus and cramps was seen. Reduction in average ankle circumference for the treatment group compared to placebo was significant at the end of the trial.

Butcher’s Broom and Premenstrual Syndrome (PMS)
In a randomized, double-blind trial, 40 women suffering PMS received either butcher’s broom extract along with diosmin or placebo for 90 days. Breast pain (Mastalgia), menstrual pain and mood were significantly improved in the treatment group compared to the placebo.

Hesperidin
Hesperidin is the main flavonoid in lemons and oranges. The peel and membrane have the highest hesperidin concentrations. Th erefore, orange juice containing pulp is richer in the flavonoid than that without pulp. Sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin. Hesperidin is classified as a citrus bioflavonoid.

Hesperidin, in combination with diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin reduces the permeability of capillaries and is an anti-inflammatory. In combination with diosmin, hesperidin has significantly improved acute internal hemorrhoids of pregnancy in a clinical open trial.

FORMULA:

Each Capsule Contains:

Diosmin (micronized) 300 mg;
Horse Chestnut (Aesculus hippocast-anum) Extract (20% escin) 167 mg;
Butcher’s Broom (Ruscus aculeatus) Extract (10% ruscogenins)(rhizome) 33 mg;
Hesperidin 33 mg.

Non-medicinal ingredients: Vegetarian capsule (cellulose, purified water) with rice starch and vegetable grade magnesium stearate (lubricant).

Recommended adult dose: 3 capsules daily with food or as directed by a health practitioner. Keep out of reach of children. Sealed for your protection and freshness.

This product does not contain artificial preservatives, colour or sweeteners; corn, dairy, soy or yeast.

ALL FORMULAS ARE MANUFACTURER TESTED AND 3RD PARTY VERIFIED FOR POTENCY

PREFERRED NUTRITION
153 Perth Street
Acton, Ontario
TEL: 888-826-9625
FAX: 888-773-7069

Website: www.pno.ca